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Istradefylline forty mg/day elevated peak concentrations and AUC of CYP3A4 substrates in medical trials. This effect was not observed with istradefylline twenty mg/day. Think about dose reduction of sensitive CYP3A4 substrates.diazepam will boost the stage or outcome of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify The